Table 1 125I-insulin blood-to-brain pharmacokinetics following intranasal insulin
From: Central nervous system insulin signaling can influence the rate of insulin influx into brain
Brain | Group | Ki (µl/g-min) | p | r | Vi (µl/g) |
|---|---|---|---|---|---|
Whole Brain | Vehicle | 1.49 ± 0.24 | 0.193 | 0.89 | 4.6 ± 0.9 |
Insulin | 2.05 ± 0.31 | 0.93 | 3.8 ± 0.9 | ||
Olfactory Bulb | Vehicle | 2.14 ± 0.41 | 0.366 | 0.76 | 11.7 ± 2.9 |
Insulin | 2.74 ± 0.52 | 0.79 | 9.7 ± 3.9 | ||
Hypothalamus | Vehicle | 3.76 ± 0.76 | 0.037 | 0.93 | 3.9 ± 3.8 |
Insulin | 0.57 ± 0.88 (ns) | 0.35 | 4.9 ± 2.9 |