Fig. 4
From: The CLDN5 gene at the blood-brain barrier in health and disease
The basic information of CLDN-5 protein
(a) The homology-based model of CLDN-5 based on the crystal structure of mouse CLDN-15 (PDB; 4P79) and (b) schematic illustration of CLDN-5 highlighting with key domains for forming CLDN dimers/oligomers and amino acids for post-translational modifications. (c) The sequence alignment of CLDN-5 with crystal structure confirmed CLDNs (CLDN-3, -4, and -15). The classic CLDN signature is highlighted by yellow and conserved cis-interaction sites are highlighted by cyan. (d) The similarity of a putative ion pathway between mouse CLDN-15 and CLDN-5 G60R is shown. The charged amino acids are highlighted by different colors