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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection

Fig. 7

Aquaporin-4 (AQP4) water channel association with infection. a Representative immunofluorescence images from an infected animal showing lectin (left), AQP4 (middle) and composite image of both the lectin and AQP4 staining (right), scale bars indicate 50 μm. The yellow dashed line indicates a typical line profile used to measure the intensity profiles as shown in b mean intensity profiles for the lectin (green) and AQP4 (red) from a representative non-infected animal (top) and a representative infected animal (bottom) taken from the single brain region. c) Mean area under curve (AUC) measurements from the individual AQP4 profiles averaged across all brain regions for non-infected (NI) animals (n = 7) and infected (Inf) animals (n = 9). Plot shows mean AUC values ± s.e.m; * p = 0.01

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Fluids and Barriers of the CNS

ISSN: 2045-8118