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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath

Fig. 2

Schematic cross-section through a cortical capillary. Left: schematic of an inter-endfoot gap showing overlap between neighboring cells and identifies symbols for some geometrical measures used in this work. Right: schematic cross-sectional cut through a capillary. The ’gaps/ring’ count for the shown cross-section is 3. The gap area fraction is measured on the outer endfoot surface (side of the extra-cellular space, ECS). For larger parenchymal microvessels (arterioles, venules), the perivascular space contains other pericytes such as smooth muscle cells and is thicker. This work is concerned with estimating the permeability of the blue astrocytic endfoot process layer relevant for fluid and substance exchange between PVS and ECS

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