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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age

Fig. 1

Study design. Pregnant CD1 were exposed to Blu e-cigarette from gestational day 5 (E5) to postnatal day 7 (PD7). At the end of the exposure, plasma nicotine and cotinine level were measured by LCMS/MS, and body weight was measured at PD7, PD23, PD45 and PD90. Mice were sacrificed and brain was extracted at every time point to evaluate blood-brain barrier (BBB) integrity by western blot and immunofluorescence. Open field test, novel object recognition test and morris water maze test were conducted at adolescent and adult time point to evaluate hyperactivity and learning-memory function

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Fluids and Barriers of the CNS

ISSN: 2045-8118