Fig. 7
From: Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery
Comparison of poststroke BBB DNA methylome profile in aging mice A Volcano plot of DEGs in aged BBB post-TE stroke condition, with log2 fold change on the x-axis and − log10(adjusted p-value) on the y-axis. Significant DEGs are red (absolute value of log2 fold change > 0.58 and adjusted p-value < 0.05), while DEGs with no statistical significance are black. B Summary of gene over-representation analysis for upregulated DEGs (top) and downregulated (bottom) DEGs from gene over-representation analysis. GO terms were chosen based on statistical (q-value < 0.01) and biological significance. C Venn diagrams demonstrating the number of DEGs with altered promoter methylation (right) or non-promoter methylation (left). D Pearson correlation between changes in gene expression and promoter methylation (left) or non-promoter methylation (right) for genes with significant changes in expression and methylation. DEGs do not correlate with methylation of their promoters (R = -0.0082, p = 0.88); however, DEGs positively correlate with methylation of non-promoter regions (R = 0.042, p = 0.027). Labeled genes are biologically significant