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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery

Fig. 5

Effect of aging on the DNA methylome profile in poststroke BBB recovery A Global DNA methylation assay demonstrates no change in global methylation in isolated microvessels (BBB) post-TE stroke in aging mice (18 months). Data represents the average percentage of 5-mC content ± SEM, n = 2. B Volcano plot of DMRs in old post-TE stroke mice, with percent methylation difference on the x-axis and − log10(q-value) on the y-axis. Significant DMRs are highlighted in red (methylation difference > 25% and q-value < 0.01), while nonsignificant DMRs are black. C Bar charts demonstrating the percentage of significant DMRs per genomic region and CpG region. Hypermethylated DMRs are represented in red and hypomethylated DMRs in blue. Summary of enriched D structural and E signaling GO terms from gene over-representation analysis. GO terms were selected based on their biological and statistical significance (q-value < 0.01)

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