Fig. 3
From: Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery
Genomic location of DMRs within poststroke BBB recovery in young (6 month) mice. Volcano plot of DMRs located within A gene promoters and B non-promoter regions, defined as any DMR outside of a promoter region (e.g. exons, introns, untranslated regions, 1-5 kb upstream of transcription start site). The x-axis is the percent methylation difference and the y-axis is the − log10(q-value). Significant DMRs (methylation difference > 25% and q-value < 0.01) are red, while DMRs lacking statistical significance are black. Violin plots demonstrate differential methylation of genes involved in (C) cell junctions, polarity and actin cytoskeleton, D angiogenesis and endothelial genes, E signaling pathways and transcription factors, F transporters and channels, and G cell adhesion and extracellular matrix. All DMRs, regardless of statistical significance, are represented for genes relevant to endothelial cell biology, with genes containing significant DMRs denoted with an asterisk (*). Gene promoter DMRs are red, and gene body DMRs are blue. Other DMRs, that are located 1-5 kb upstream of transcription start site or no genomic location, are gray