Fig. 1

Comparing gene expression in meninges isolated from young and aged mice. A Meninges were isolated from mice at different ages, total RNA was isolated, and gene expression was determined by RNASeq. Shown is a multi-dimensional scaling analysis of 21 samples based on the top 250 differentially regulated genes. B Volcano-plot of differential gene expression plotted as log₁₀ fold change vs. statistical significance of observed differential gene expression expressed as -log₂ of the Benjamini–Hochberg adjusted p-value