Fig. 1

The tPA/PAI-1 axis controls NVC. A Colormap corresponds to the activation map related ∆CBF changes during whisker stimulations of tPA^Null, PAI-1^KO mice and their wild type littermates. Maps were obtained by subtraction of stimulation frames and resting frames. Warm colours indicate an elevation of CBF during whisker stimulations. B, D Time course of % CBF increase (mean ± SEM) during whisker stimulations () of tPA^Null (B) and PAI-1^−/− (D) mice () and their littermates (). C, E Box plots show the variations of % CBF increase from baseline during whisker stimulations of tPA^Null (C) and PAI-1^−/− (E) mice and their littermates. Box plots with medians, 1st and 3rd quartiles, min and max with values for each mouse. *p < 0.05 from tPA^WT or PAI-1^WT, Mann–Whitney test, n = 18/16 tPA^WT/tPA^Null, n = 10 PAI-1^WT/PAI-1^KO