Skip to main content
Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

Fig. 6

Effect of viral PAMP exposure (Poly I:C 1 µg/mL or vehicle for 24 h) on total ABCB1/ABCG2, cytokines and chemokine mRNA levels in human primary fetal brain endothelial cells (hfBECs) derived in early and mid-gestation. Relative ABCB1/ABCG2, cytokines (IL-6, IL-8, INFα) and chemokine (CCL2) mRNA expression in early (A–F) and mid- (G–L) gestation hfBECs. Data are expressed as means ± SD. N = 6/group (if N < 6, an outlier has been removed). Statistical differences were tested using a paired t-test. *p < 0.05. mRNA values from LPS (Fig. 5) and Poly I:C treated groups were compared to the same vehicle controls (treated with water), except for CCL2 in early gestation (F) which was run in a separate PCR

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118