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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier

Fig. 1

Bacterial and viral PAMPs decreased P-gp activity in early and mid-gestation human primary fetal brain endothelial cells (hfBECs), in a time and dose-specific manner. Percent change in P-gp activity in hfBECs following treatment with LPS (A–D), Poly I:C (E–H) or ssRNA (I–L) compared to control (water for LPS and Poly I:C; Lyovec for ssRNA) at 4 h and 24 h. P-gp activity is displayed as percent mean ± SD change from control. N = 6/group. Statistical differences were tested using Friedman test, followed by Dunn’s multiple comparisons test comparing all doses against the respective control group. Overall effects of treatment, within each age and timepoint, are presented at the top of each graph. Specific dose-effects are indicated as follows; *p < 0.05, **p < 0.01, ***p < 0.001

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Fluids and Barriers of the CNS

ISSN: 2045-8118