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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption

Fig. 3Fig. 3

KEGG pathway enrichment analysis of DEGs in 0.25 MPa and 0.42 MPa. (AB) KEGG pathway enrichment scatter plot of DEGs in the 0.25 MPa (A) and 0.42 MPa (B). The Y-axis shows the KEGG pathway of the top 10 KEGG enriched pathways (A) and the top 20 KEGG enriched pathways (B). The X-axis represents the rich factor, which was calculated by the ratio of the number of differentially expressed transcripts divided by the number of annotated transcripts in this pathway. This indicates the degree of KEGG pathway enrichment. The dot size and color represent the gene number and log10 FDR value, respectively. The low FDR values are in blue, and the high values are in red. (CD) The interaction network of KEGG pathway enrichment analysis of hub genes at 0.25 MPa (C) and 0.42 MPa (D) at 48 h post-BBBD. The circle colors of genes represent expression levels. Red and blue colors indicate that the nodes are upregulated and downregulated, respectively. The area of each node indicates the degree of connectivity between the pathways and genes. The four downregulated hub genes were involved in the top 20 pathways (C). The 58 upregulated genes were involved in the top 10 pathways (D)

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