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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins

Fig. 4

Exogenous laminin-111 and -111ΔLG1-5 are eliminated from the brain via the perivascular system. A Representative images of Alexa-555 labeled laminin-111 (red) and -111ΔLG1-5 (red) in the brain at various time points after intracerebral injection. B Quantification of total laminin levels at each time point in A. n = 4, *p = 0.0286 by Mann–Whitney U test. C Quantification of vessel-associated laminin levels at 12 and 24 h after intracerebral injection in A. n = 4, *p = 0.0286 by Mann–Whitney U test. D, E Quantification of Alexa-555 fluorescent intensity in the CSF at 15 min (D) and 24 h (E) after intracerebral injection. n = 5–6, *p = 0.0152 and **p = 0.0079 by Mann–Whitney U test. Data are represented as mean ± SD

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