Table 2 Comparison of paraclinical profiles between normal and elevated Qalb groups of neuronal surface antibody-associated autoimmune encephalitis
From: Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis
Total (n = 93) | Normal Qalb group (n = 60) | Elevated Qalb group (n = 33) | P value | |
|---|---|---|---|---|
CSF analyses, median (IQR) | ||||
WBC, × 106/L | 6.0 (2.0, 15.0) | 4.0 (2.0, 8.0) | 11.0 (4.0, 67.0) | 0.001 |
Protein, mg/dL | 36.2 (29.2, 50.1) | 30.8 (26.6, 36.4) | 62.4 (43.8, 102.2) | < 0.001 |
CSF IgG, mg/L | 32.2 (23.9, 61.4) | 27.3 (21.3, 34.0) | 77.3 (53.6, 207.0) | < 0.001 |
CSF albumin, mg/L | 207.0 (158.0, 336.0) | 177.5 (132.3, 207.0) | 426.0 (300.0, 676.5) | < 0.001 |
Serum IgG, g/L, median (IQR) | 11.0 (9.6, 13.8) | 11.1 (9.4, 13.9) | 10.9 (9.7, 13.7) | 0.866 |
Serum albumin, g/L, median (IQR) | 37.7 (34.1, 42.1) | 37.0 (34.1, 41.8) | 38.5 (34.3, 42.9) | 0.503 |
IgG index, median (IQR) | 0.53 (0.46, 0.63) | 0.52 (0.45, 0.58) | 0.59 (0.44, 0.92) | 0.065 |
Brain lesions, n (%) | 40 (43.0) | 20 (33.3) | 20 (60.6) | 0.011 |
Temporal lobe | 32 (34.4) | 17 (28.3) | 15 (45.5) | 0.096 |
Frontal lobe | 17 (18.3) | 7 (11.7) | 10 (30.3) | 0.026 |
Parietal lobe | 8 (8.6) | 2 (3.3) | 6 (18.2) | 0.040 |
Occipital lobe | 4 (4.3) | 2 (3.3) | 2 (6.1) | 0.931 |
Basal ganglion | 6 (6.5) | 1 (1.7) | 5 (15.2) | 0.036 |
Brainstem | 5 (5.4) | 0 (0.0) | 5 (15.2) | 0.009 |
Lesions with contrast | 11/50 (22.0) | 4/28 (14.3) | 7/22 (31.8) | 0.254 |