Fig. 1From: Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologiesTimeline tree of important discoveries pertaining to CSF. Timeline tree of significant events and discoveries pertaining to the choroid plexus and CSF production. The branches illustrate the passage of time, which spans over millennia, beginning with the first clinical description of CSF in an ancient Egyptian papyrus dating from 1500 BC, the first confirmation of CSF as a liquid during the Renaissance, and the modern description of CSF transport as the third circulation by Harvey CushingBack to article page