Fluids and Barriers of the CNS

Table 3 Results of hierarchical multiple regression analysis for MMSE with brain structures

From: Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age

	All individuals (n = 1,356)					Individuals without DESH (n = 1,331)
	Brain structure	β_STD	P-value	ΔR²		Brain structure	β_STD	P-value	ΔR²
1	SHM	0.0993	0.0002*	0.0090	1	SHM	0.0910	0.0006*	0.0076
2	VS	−0.0916	0.0010*	0.0068	2	VS	−0.0932	0.0009*	0.0071
3	Accumbens	0.0919	0.0016	0.0062	3	Accumbens	0.0914	0.0019	0.0062
4	Hippocampus	0.0904	0.0029	0.0056	4	Middle temporal	0.0901	0.0020	0.0061
5	Middle temporal	0.0852	0.0033	0.0054	5	Precuneus	0.0926	0.0024	0.0059
6	SF	−0.0783	0.0042	0.0052	6	Hippocampus	0.0926	0.0024	0.0059
7	Precuneus	0.0863	0.0043	0.0051	7	Lateral occipital	0.0807	0.0051	0.0050
8	Lateral occipital	0.0808	0.0047	0.0050	8	Amygdala	0.0819	0.0051	0.0050
9	Supramarginal	0.0799	0.0052	0.0049	9	Banks sts	0.0822	0.0053	0.0050
10	Amygdala	0.0811	0.0052	0.0049	10	Supramarginal	0.0797	0.0056	0.0049
11	Lingual	0.0708	0.0107	0.0041	11	Lingual	0.0725	0.0096	0.0043
12	Transverse temporal	0.0685	0.0125	0.0039	12	SF	-0.0704	0.0104	0.0042
13	Superior temporal	0.0704	0.0161	0.0036	13	Superior temporal	0.0724	0.0141	0.0039
14	Lateral orbitofrontal	0.0658	0.0196	0.0034	14	Superior frontal	0.0756	0.0143	0.0039
15	Superior frontal	0.0712	0.0200	0.0034	15	Inferior parietal	0.0714	0.0188	0.0035
16	Inferior parietal	0.0675	0.0254	0.0031	16	Inferior temporal	0.0649	0.0220	0.0034
17	Banks sts	0.0647	0.0263	0.0031	17	Transverse temporal	0.0632	0.0225	0.0033
18	Inferior temporal	0.0595	0.0347	0.0028	18	Lateral orbitofrontal	0.0641	0.0236	0.0033
19	Precentral	0.0711	0.0367	0.0028	19	Precentral	0.0630	0.0669	0.0022
20	Entorhinal	0.0487	0.0659	0.0021	20	Entorhinal	0.0469	0.0784	0.0020

After controlling for age, sex, education, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, coronary artery disease, heart failure, BMI, history of smoking, MRI scanner, Fazekas score, lacunar infarction, microbleeds and perivascular space (Block 1), each brain structure was entered in Block 2. For each analysis, the top 20 brain structures are shown in descending order of ∆R²
^*The significance level was P < 0.0011 to correct for 46 modeling analyses
BMI body mass index, DESH disproportionately enlarged subarachnoid-space hydrocephalus, MMSE Mini-Mental State Examination, SF Sylvian fissure, SHM subarachnoid space at high convexity and midline, VS ventricular system

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ISSN: 2045-8118

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