Fluids and Barriers of the CNS

Table 2 Multivariate analysis of DESH-related regions

From: Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age

VS
Variables	All individuals (n = 1,356)		Individuals without DESH (n = 1,331)
Variables	β_STD	P-value	β_STD	P-value
Age	0.3199	< 0.0001*	0.3082	< 0.0001*
Female sex	−0.2343	< 0.0001*	−0.2423	< 0.0001*
Education (≤ 9 years)	−0.0243	0.3478	−0.0126	0.6329
Hypertension	−0.0080	0.7602	−0.0085	0.7486
Diabetes mellitus	0.0447	0.0772	0.0391	0.1279
Dyslipidemia	−0.0428	0.0913	−0.0429	0.0953
Atrial fibrillation	0.0146	0.5592	0.0186	0.4644
Coronary artery disease	0.0225	0.3718	0.0072	0.7777
Heart failure	0.0094	0.7067	0.0160	0.5306
BMI	−0.0151	0.5538	−0.0126	0.6282
History of smoking	−0.0129	0.6835	−0.0134	0.6785
Fazekas score	0.1473	< 0.0001*	0.1504	< 0.0001*
Lacunar infarction	−0.0571	0.0692	−0.0803	0.0117*
Microbleeds	0.0112	0.6673	0.0078	0.7668
Perivascular space	0.0425	0.0888	0.0411	0.1047

SF
Variables	All individuals (n = 1,356)		Individuals without DESH (n = 1,331)
Variables	β_STD	P-value	β_STD	P-value
Age	0.3280	< 0.0001*	0.3152	< 0.0001*
Female sex	−0.0704	0.0310*	−0.0588	0.0756
Education (≤ 9 years)	0.0104	0.6955	0.0225	0.4029
Hypertension	0.0206	0.4416	0.0123	0.6488
Diabetes mellitus	0.0228	0.3766	0.0231	0.3771
Dyslipidemia	−0.0299	0.2468	-0.0213	0.4157
Atrial fibrillation	0.0539	0.0355*	0.0767	0.0031*
Coronary artery disease	0.0189	0.4622	0.0041	0.8737
Heart failure	0.0166	0.5166	0.0212	0.4129
BMI	−0.0036	0.8888	0.0046	0.8623
History of smoking	0.0446	0.1677	0.0490	0.1361
Fazekas score	0.0707	0.0259*	0.0629	0.0503
Lacunar infarction	0.0046	0.8849	0.0072	0.8251
Microbleeds	0.0093	0.7268	0.0169	0.5295
Perivascular space	0.0456	0.0733	0.0538	0.0372*

SHM
Variables	All individuals (n = 1,356)		Individuals without DESH (n = 1,331)
Variables	β_STD	P-value	β_STD	P-value
Age	−0.1104	0.0002*	−0.0833	0.0063*
Female sex	0.0717	0.0363*	0.0650	0.0619
Education (≤ 9 years)	0.0015	0.9563	−0.0158	0.5765
Hypertension	−0.0632	0.0246*	−0.0624	0.0288*
Diabetes mellitus	−0.0006	0.9809	0.0061	0.8234
Dyslipidemia	−0.0052	0.8469	−0.0159	0.5635
Atrial fibrillation	0.0064	0.8105	−0.0078	0.7741
Coronary artery disease	−0.0124	0.6459	0.0041	0.8808
Heart failure	−0.0120	0.6538	−0.0187	0.4930
BMI	−0.0311	0.2559	−0.0360	0.1963
History of smoking	−0.0306	0.3680	−0.0355	0.3045
Fazekas score	−0.1601	< 0.0001*	−0.1525	< 0.0001*
Lacunar infarction	0.0242	0.4735	0.0352	0.3024
Microbleeds	0.0074	0.7920	0.0063	0.8242
Perivascular space	−0.0822	0.0022*	−0.0888	0.0011*

*The significance level was P < 0.05
BMI body mass index, DESH disproportionately enlarged subarachnoid-space hydrocephalus, SF Sylvian fissure, SHM subarachnoid space at high convexity and midline, VS ventricular system

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