| | Body weight (g) | Glucose (mg/dl) | Insulin (ng/dl) |
|---|
Control | 28.50 ± 1.84 | 122.71 ± 9.58 | 0.75 ± 0.29 |
Control-HFD | 44.50 ± 4.80†† | 114.00 ± 7.15 | 5.52 ± 2.28†† |
APP/PS1 | 28.61 ± 0.87 | 129.83 ± 4.20 | 0.69 ± 0.12 |
APP/PS1-HFD | 42.95 ± 2.54†† | 118.17 ± 9.94 | 7.13 ± 0.99†† |
db/db | 48.88 ± 2.83†† | 484.50 ± 33.73‡‡ | 6.90 ± 1.76†† |
APP/PS1xdb/db | 42.87 ± 2.09†† | 448.40 ± 68.20‡‡ | 6.68 ± 2.08†† |
- Body weight [F(5,35) = 13.04, ††p < 0.01 vs. Control and APP/PS1] and insulin levels [F(5,44) = 5.32, ††p < 0.01 vs. Control and APP/PS1] were significantly increased in animals on HFD, db/db and APP/PS1xdb/db mice, while glucose levels were significantly higher in diabetic mice [F(5,39) = 52.19, ‡‡p < 0.01 vs. Control, Control-HFD, APP/PS1 and APP/PS1-HFD]. Data are representative of 5–12 mice (Control n = 7, Control-HFD n = 7, APP/PS1 n = 12, APP/PS1-HFD n = 6, db/db n = 8, APP/PS1xdb/db n = 5)
