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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Fig. 1

Aβ levels are altered in prediabetic and T2D mice. Soluble Aβ40 is increased in APP/PS1xdb/db mice when compared with APP/PS1 and prediabetic-APP/PS1 animals, [F(3,44) = 5.03, **p = 0.004 vs. rest of the groups] while differences did not reach statistical significance for soluble Aβ42 [F(3,36) = 2.20, p = 0.105]. On the other hand insoluble Aβ40 is reduced in APP/PS1xdb/db mice [F(3,40) = 5.064 **p = 0.003 vs. rest of the groups] and a similar trend is observed for insoluble Aβ42 although differences are not statistically significant [F(3,27) = 0.798, p = 0.506] (APP/PS1-RD n = 9–12, APP/PS1-HFD n = 7–12, APP/PS1 n = 8–12 and APP/PS1xdb/db n = 7–12) (mean ± SEM). While oligomeric Aβ is slightly higher in APP/PS1xdb/db mice, differences are not statistically significant [F(3,16) = 1.25, p = 0.323] (APP/PS1-RD n = 5, APP/PS1-HFD n = 5, APP/PS1 n = 4 and APP/PS1xdb/db n = 6) (mean ± SEM)

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Fluids and Barriers of the CNS

ISSN: 2045-8118