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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

Fig. 5

Effects of N. meningitidis infection on expression of proinflammatory cytokines in iBECs of mono- and co-culture models. a Relative expression of CXCL8, CXCL1, CXCL2, CCL20, and IL6 transcripts in iBECs from direct co-culture with LMCs with (light bars) or without (dark bars) N. meningitidis infection, quantified by qPCR and normalized to 18S rRNA. b Concentration of IL-8 in the cell culture medium, determined using ELISA. Data presented as mean ± SD from four independent experiments and iBEC differentiations performed in duplicate (n = 6–8). *p < 0.05, **p < 0.01, ***p < 0.001; Student's t test; infected vs. uninfected control (blue/black asterisks directly over bars), mono vs co-culture (asterisks above brackets)

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