Fig. 1
From: Human intracranial pulsatility during the cardiac cycle: a computational modelling framework
a Sketch of the domains representing the brain parenchyma (\(\Omega _p\), pink) and the CSF-filled spaces (\(\Omega _f\), blue). The interface of both domains is denoted by \(\Sigma \). Additionally, the boundaries \(\Gamma _{\mathrm{skull}}\) at the skull, \(\Gamma _{\text {SC}}\) at the spinal cord and \(\Gamma _{\text {SAS}}\) at the spinal SAS are highlighted; b Net blood inflow during the cardiac cycle with four different phases: (I) early systole - high net blood inflow; (II) end of net blood inflow phase; (III) brain equilibrium phase (arterial inflow and venous outflow almost match); (IV) high net outflow of blood (data extracted from Balédent [5]); c The MRI image used for the mesh generation and the segmented parts of the ventricular system: LV lateral ventricles, FM foramina of Monro, V3 third ventricle, AQ aqueduct of Sylvius, V4 fourth ventricle, MA median aperture, SAS probe point in the subarachnoid space; d sagittal view of the mesh, displaying the ventricular system, cranial SAS (both light blue) brain parenchyma (red)