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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport

Fig. 3

Transcriptome profiling after 17β-estradiol treatment. A Experimental setup. 3 biological replicates were sequenced per condition. B Volcano plot depicting relative gene expression (17b-estradiol treatment relative to DMSO). Blue dots indicate differentially expressed genes with p < 0.05, and red dots indicate differentially expressed genes with p < 0.05 and a fold change (FC) greater than 1.5. The full set of differentially expressed genes is provided in Additional file 1: Table S5. C Gene ontology analysis for enriched signaling pathways (false-discovery rate less than 0.05) in response to 17β-estradiol treatment relative to DMSO. D Normalized counts per million for genes encoding solute carrier transporters. Data are represented as mean ± standard deviation from 3 biological replicates. E Normalized counts per million for LEPR. Data are represented as mean ± standard deviation from 3 biological replicates

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Fluids and Barriers of the CNS

ISSN: 2045-8118