Fig. 2
From: VHHs as tools for therapeutic protein delivery to the central nervous system
Effect on Aβ1–40 levels after systemic dosing with anti-mouse TfR/BACE1 antibody. Quantification of Aβ1–40 concentrations in C57BL/6 J mouse plasma A and brain B 24 h after an intravenous injection of PBS, 1A11AM-aGFP (167 nmol/kg) or 1A11-Nb62 (high dose: 167 nmol/kg; low dose: 16.7 nmol/kg). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: one-way ANOVA with Dunett’s multiple comparisons test compared to PBS injected mice (*p < 0.05, ***p < 0.001)