Fig. 1
From: VHHs as tools for therapeutic protein delivery to the central nervous system
Overview and binding kinetics of anti-TfR/BACE1 antibodies. A The fusion of 1A11WT to two copies of Nb62 resulted in a homodimeric antibody where Nb62 was fused to the light chain of 1A11WT (left). 1A11AM-Nb62 (right) is a heterodimeric antibody where both the BACE1 inhibiting Fab fragment of 1A11AM, as well as Nb62, were each individually fused to one of the respective Fc constant domains. B Binding of anti-TfR/BACE1 antibodies to biotinylated mTfR immobilized on streptavidin biosensors is shown. C Binding kinetics were calculated and summarized