Fig. 1
From: The choroid plexus and its role in the pathogenesis of neurological infections
Overview of CSF production and junctional properties of the blood-CSF barrier. A A diagram indicating the bulk flow of CSF following its production from the CP. The CSF flows in a unilateral direction through the ventricular system, and multidirectionally throughout the subarachnoid space. B A coronal section showing the drainage of CSF. Three distinct sites of CSF drainage are highlighted—through dural lymphatics, arachnoid granulations, and through perivascular space (inset) where it enters the brain parenchyma and exits via perivenous routes. C A molecular view of CSF production and several important transporters. Passive diffusion of water and solutes occur through the fenestrae of the blood vessels. Differential transport of ions across the membrane creates an electrochemical gradient that drives water transport via AQP1. Direct coupling of water with transporters occurs, NKCC1. D An overview of the polarized junctional proteins found in the CP epithelium – tight junctions, adherens junctions, desmosomes, and gap junctions are present, along with their scaffolding proteins. Created with BioRender.com