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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model

Fig. 4

Dose of cavitation affects tracer accumulation in a dose dependent and size dependent manner. A-C Blood–brain barrier permeability increases significantly with LIFU mediated for doses ranging between 0.1–1.5CD for AIB, TxRed and Cs Blue respectively. D The accumulation of tracers is size dependent and shows a linear relation with cavitation dose. E Higher cavitation dose above 1CD show erythrocyte extravasation as observed by eosinophil staining (p < 0.01)

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