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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome

Fig. 1

α-syn RT-QuIC kinetic parameters in the study cohort. a Representation of the analyzed kinetic parameters. The Lag phase represents the time interval between the beginning of the reaction and the time in which the fluorescent signal crosses the threshold (dashed line); the I max is the maximum fluorescence value reached by the curve. b Differences in the mean normalized fluorescence emission of α-syn RT-QuIC positive cases between iNPH (red line) and DLB (blue line) clinical cases. The black dashed line represents the threshold. The error bars indicate the standard deviation (SD). c The comparison of kinetic parameters of α-syn RT-QuIC positive cases between the two groups (iNPH and DLB) shows statistically significant differences in lag phase and I max (***p ≤ 0.001). d Distribution analysis of positive replicates in the iNPH and DLB cohorts. In b, c, and d: iNPH, n = 60 and DLB, n = 45. Statistical analysis was performed by Chi-square test (***p ≤ 0.001)

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Fluids and Barriers of the CNS

ISSN: 2045-8118