Table 1 List of the variables calculated during the simulations
Variable name | Description |
|---|---|
\(\Delta {V}_{c}\) | CSF volume change cranially, from supine baseline |
\(\Delta {V}_{s}\) | CSF volume change spinally, from supine baseline |
\(\Delta {V}_{ONSAS}\) | CSF volume change in the ONSAS, from supine baseline |
\({Q}_{ou{t}_{c}}\) | CSF outflow, cranially |
\({Q}_{ou{t}_{s}}\) | CSF outflow, spinally |
\({Q}_{ou{t}_{ONS}}\) | CSF outflow across the optic nerve sheath |
\({Q}_{c-s}\) | CSF flow between the cranial and spinal compartment (positive in cranial-spinal direction) |
\({Q}_{c-ONSAS}\) | CSF flow between he cranial compartment and the ONSAS |
\({Q}_{LC}\) | CSF inflow from the eye across the lamina cribrosa |
\({p}_{c}\) | Pressure in the cranial compartment (ICP) Hydrostatic ref: auditory meatus |
\({p}_{s}\) | Pressure in the spinal compartment Hydrostatic ref: venous hydrostatic indifference point |
\({p}_{ONSAS}\) | Pressure in the ONSAS Hydrostatic ref: the lamina cribrosa |
\({p}_{{c}_{LC}}\) | ICP referenced to the hydrostatic level of the lamina cribrosa |
\({p}_{vc}\) | Dural sinus pressure Hydrostatic ref: auditory meatus |
\({R}_{ONSAS}\) | Total flow resistance in the ONSAS |
\({R}_{LC}\) | Resistance to flow across the lamina cribrosa |
\({h}_{s-c}\) | Vertical height from the spinal to the cranial reference points |
\({h}_{c-lc}\) | Vertical height from the cranial reference point to the lamina cribrosa |
\(\kappa\) | Permeability of the ONSAS* |
\({r}_{ONS}\) | Radius of the optic nerve sheath* |
\({r}_{ON}\) | Radius of the optic nerve* |
\({C}_{ONSAS}\) | Total compliance of the ONSAS |
\(D\) | Distensibility of the ONSAS* |
\(\varphi\) | ONSAS porosity* |
\(\alpha\) | Upper body tilt-angle |