Fig. 7
From: Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Ablation of the NMDA receptor in endothelial cells induces decrease in the brain vasculature. A and B (A) Brains from the 3, 6, and 9 months old endothelial cell specific NMDA receptor subunit 1 (NR1) knock out (NR1fl/fl-Tie2Cre+) and its littermate control (NR1fl/fl-Tie2Cre−) was stained with CD31 a marker for the brain endothelial cells. Scale bar indicates 200 μm. B Density of brain vasculature (percentage of brain area) was quantified by Image J and depicted as graphs (** indicates where p < 0.01, two-tailed unpaired student t-test, 3 different area each from 3 different animals)