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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption

Fig. 2

Transcriptomic analysis of isolated brain microvessels from TEKCRIF1 KO mice. A Volcano plot showing differentially expressed genes in isolated cerebral microvessels from TEKCRIF1 KO mice compared with those from WT mice (n = 3 mice/group). B FPKM values for the Crif1 (Gadd45gip1) gene. C Crif1 mRNA level, analyzed by qPCR (n = 6 mice/group). Data are presented as means ± SD (**P < 0.01, ***P < 0.001 vs. WT). (D) Up- and down-regulated pathways in isolated brain microvessels from TEKCRIF1 KO mice. Pathways were categorized using the KEGG pathway database. E Network analysis by IPA. Blue denotes inhibited pathways and orange denotes activated pathways. F List of most potent upstream regulators related to Crif1 deletion in ECs identified through IPA upstream regulator analysis

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