Fig. 1

PHH associates with elevated levels of LPA, excessive brain water and ventriculomegaly.  A Quantification of LPA levels in CSF sampled from patients with SAH, n = 12 (red) and control subjects, n = 14 (black). B Quantification of LPA levels in CSF sampled from IVH (inset) rats, n = 8 (red) and sham operated rats, n = 9 (black). C Brain water content quantified from LPA-treated rats, n = 6 (orange) and sham operated rats, n = 6 (black). D Representative MRI brain sections (upper panel, horizontal; lower panel, 3D projections) from rats 24 h post-surgery, n = 3 of each. E Ipsilateral ventricular volume quantification from MRI sections from LPA-treated rats, n = 3 (orange) and sham operated rats, n = 3 (black) 24 h post-surgery. Statistical evaluation with Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001