Skip to main content
Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Extracellular vesicles through the blood–brain barrier: a review

Fig. 1

Uptake and transcytosis mechanisms for crossing of extracellular vesicles through the BBB. The figure shows four uptake mechanisms that have been evaluated and proposed for the active transport of EVs across the BBB and the authors that have described evidence to support them: A Macropinocytosis [30, 31]. B Clathrin-mediated endocytosis [30, 31]. C Caveolae-mediated endocytosis [30]. D Adsorptive-mediated endocytosis [28]. The fate of EVs after internalization include recycling to the plasma membrane, degradation of EVs by lysosomes, and final transcytosis of EVs and their cargos to the extracellular space. EVs extracellular vesicles, BBB blood brain barrier, MVB multivesicular body, TJ tight junctions

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118