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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis

Fig. 3

Treatment with CYM-5442 reduced circulating lymphocytes after TBI. A Total number of lymphocytes. Mice treated with 3 mg/kg CYM-5442 showed reduced lymphocyte numbers at 3 h after TBI. B Total number of leukocytes. Mice treated with 3 mg/kg CYM-5442 showed reduced leukocyte numbers at 3 h after TBI. The results showed no significant differences in the lymphocyte and leukocyte counts at days 1, 3, and 7 between the CYM-5442 (3 mg/kg) group and the Sham and TBI + Vehicle groups. Two-way ANOVA and Tukey’s multiple comparisons test were used for statistical analyses, n = 6/group. Those experimental groups in receipt of the vehicle/CYM-5442 also were subjected to TBI. All values are presented as the mean ± SD

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Fluids and Barriers of the CNS

ISSN: 2045-8118