Table 2 Model predicted pharmacokinetic parameters of gadobutrol in blood

Number of subjects

28

13

14

14

15

63

11

3

T_{1/2, abs} (h)

4.57 ± 3.31 (72%)

4.12 ± 2.14 (52%)

4.86 ± 2.93 (60%)

3.79 ± 2.91 (77%)

2.32 ± 1.61^b (69%)

4.15 ± 3.07 (74%)

4.62 ± 3.86 (84%)

4.92 ± 3.88

(79%)

T_max (h)

7.49 ± 4.09 (55%)

9.00 ± 4.27

(47%)

8.89 ± 2.98 (34%)

7.09 ± 3.44 (49%)

5.8 ± 2.01

(35%)

9.85 ± 5.4 ^a (55%)

8.14 ± 3.44 (42%)

12.33 ± 7.17

(58%)

C_max (μM)

0.70 ± 0.38 (54%)

0.66 ± 0.31 (47%)

0.55 ± 0.23 (42%)

0.90 ± 0.58 (64%)

0.83 ± 0.27 (33%)

0.67 ± 0.48 (72%)

0.50 ± 0.17 ^a (34%)

0.54 ± 0.49

(91%)

T_lag (h)

0.74 ± 0.67 (91%)

1.20 ± 0.59 ^a (49%)

0.74 ± 0.42 (57%)

1.03 ± 0.89

(86%)

0.88 ± 0.55 (62%)

1.16 ± 0.77 ^a

(66%)

1.12 ± 0.87 (78%)

0.96 ± 0.82

(85%)

AUC_0-∞ (μM h)

12.58 ± 2.55

(20%)

15.05 ± 3.96

(26%)

13.65 ± 6.13

(45%)

15.36 ± 5.92

(39%)

15.67 ± 4.54^a

(29%)

18.49 ± 8.24^c

(45%)

12.79 ± 4.68

(37%)

13.44 ± 3.6

(27%)