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Table 1 Demographic overview

From: Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders

 

Patient category

REF

PC

AC

SIH

IIH

iNPH

Comm. HC

Non-comm. HC

Number of subjects

28

13

14

14

15

63

11

3

Ith dose of gadobutrol

 0.10 mmol

0

0

0

0

0

13

0

0

 0.25 mmol

3

0

2

4

1

17

3

0

 0.50 mmol

25

13

12

10

14

33

8

3

Gender (male/female)

6/22

1/12

8/6a

5/9

2/13

37/26b

7/4a

2/1

Age (years)

39 ± 12

36 ± 13

52 ± 17a

50 ± 10b

33 ± 11

72 ± 6c

49 ± 13a

43 ± 29

Height (cm)

172 ± 8

170 ± 5

176 ± 10

172 ± 10

165 ± 7b

173 ± 9

178 ± 12

171 ± 7

Weight (kg)

82 ± 15

80 ± 15

82 ± 13

78 ± 23

88 ± 17

81 ± 16

84 ± 20

80 ± 24

BMI (kg/m2)

28 ± 5

28 ± 4

27 ± 3

26 ± 6

32 ± 5a

27 ± 4

26 ± 5

27 ± 6

GFR (ml/min)

103 ± 12

98 ± 12

86 ± 16b

95 ± 15

105 ± 13

77 ± 14c

92 ± 18

104 ± 15

  1. Data presented as mean ± SD. Differences from the reference group were determined by independent samples t-test for continuous variables and by Fishers exact test for categorical variables (aP < 0.05, bP < 0.01, cP < 0.001). Patient categories: AC Arachnoid cyst, Comm HC communicating hydrocephalus, IIH idiopathic intracranial hypertension, iNPH idiopathic normal pressure hydrocephalus, Non-comm HC non-communicating hydrocephalus, PC pineal cyst, REF reference cohort, SIH spontaneous intracranial hypotension