Fig. 3From: Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disordersDose linearity of intrathecally administered gadobutrol. Mean individual posterior predicted concentration of gadobutrol following intrathecal administration of A 0.1Â mmol, B 0.25Â mmol and C 0.5Â mmol of gadobutrol; also shown is the D dose-normalized concentrations, demonstrating dose linearityBack to article page