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Table 2 17 proteins for which there were significant differences in protein expression levels in capillary samples between the Aβ abundant CAA (ADNC +/CAA +/H) and non-CAA groups (ADNC +/CAA − and ADNC −/CAA −)

From: Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method

Molecule name

Relative protein expression level normalized by the average in ADNC-/CAA- capillary samples

Benjamini & Hochberg (BH) adjusted p-value for the difference in protein expression levels between two groups in capillary sample

ADNC +/CAA +/H

ADNC +/CAA +/L

ADNC +/CAA-

ADNC-/CAA-

ADNC +/CAA +/H vs ADNC +/CAA +/L

ADNC +/CAA +/H vs ADNC +/CAA-

ADNC +/CAA +/H vs ADNC-/CAA-

ADNC +/CAA +/L vs ADNC +/CAA-

ADNC +/CAA +/L vs ADNC-/CAA-

ADNC +/CAA- vs ADNC-/CAA-

MEAN ± SD

MEAN ± SD

MEAN ± SD

MEAN ± SD

Fibrosis related protein

 DUSP3

0.373 ± 0.120

0.842 ± 0.344

0.800 ± 0.150

1.00 ± 0.25

0.180

0.0134*

0.0179*

0.851

0.618

0.243

ROS related protein

 PGM1

1.70 ± 0.05

1.09 ± 0.49

1.06 ± 0.42

1.00 ± 0.31

0.197

0.0459*

0.0163*

0.925

1.00

0.971

 GSTO1

2.32 ± 0.45

1.50 ± 0.47

0.877 ± 0.461

1.00 ± 0.62

0.189

0.0289*

0.0394*

0.170

0.286

0.731

Antioxidant related protein

 GFAP

1.99 ± 0.21

1.85 ± 0.21

1.26 ± 0.39

1.00 ± 0.26

0.460

0.0289*

0.00585*

0.0512

0.00668*

0.287

 PRDX6

1.98 ± 0.11

1.23 ± 0.39

0.998 ± 0.178

1.00 ± 0.41

0.0637

0.000393*

0.00712*

0.542

0.546

0.990

Akt related protein

 SNCG

0.215 ± 0.051

0.698 ± 0.457

1.05 ± 0.29

1.00 ± 0.37

0.286

0.00464*

0.0101*

0.407

0.444

0.798

 PFDN2

0.467 ± 0.075

0.252 ± 0.031

1.18 ± 0.26

1.00 ± 0.43

0.0153*

0.00346*

0.0437*

0.00123*

0.0171*

0.454

Caspase related protein

 TLN2

0.430 ± 0.165

0.947 ± 0.306

0.959 ± 0.167

1.00 ± 0.15

0.124

0.0142*

0.0161*

0.952

0.944

1.00

 ATP2A2

0.504 ± 0.077

0.780 ± 0.071

0.767 ± 0.125

1.00 ± 0.32

0.0615

0.0307*

0.0307*

0.865

0.221

0.246

 CCT7

0.710 ± 0.063

0.902 ± 0.171

0.982 ± 0.130

1.00 ± 0.16

0.282

0.0441*

0.0357*

0.613

0.682

0.852

 ELAVL1

0.548 ± 0.076

0.647 ± 0.150

1.04 ± 0.19

1.00 ± 0.31

0.436

0.0134*

0.0433*

0.0548

0.113

0.825

Others

 VARS

0.356 ± 0.088

0.640 ± 0.038

0.822 ± 0.233

1.00 ± 0.25

0.0204*

0.0138*

0.0110*

0.164

0.0281*

0.278

 HGSNAT

1.89 ± 0.28

0.959 ± 0.515

0.804 ± 0.198

1.00 ± 0.27

0.104

0.00670*

0.0140*

0.762

0.905

0.342

 PLPBP

0.810 ± 0.072

1.18 ± 0.06

1.20 ± 0.13

1.00 ± 0.09

0.00731*

0.0110*

0.0274*

0.862

0.0296*

0.0318*

 PPA1

1.55 ± 0.20

1.04 ± 0.10

0.509 ± 0.332

1.00 ± 0.26

0.0269*

0.00918*

0.0325*

0.0458*

0.755

0.0380

 SV2B

0.425 ± 0.045

0.829 ± 0.079

0.942 ± 0.121

1.00 ± 0.23

0.00309*

0.000818*

0.00455*

0.245

0.209

0.623

 C2CD2L

0.497 ± 0.215

0.852 ± 0.434

1.08 ± 0.07

1.00 ± 0.15

0.409

0.0221*

0.0347*

0.472

0.592

0.536

  1. The 17 proteins listed in this table satisfy both the following (1) and (2) criteria; proteins that showed significant differences in protein expression levels (1) between ADNC +/CAA +/H and ADNC +/CAA − groups, and (2) between ADNC +/CAA +/H and ADNC −/CAA − groups, for the collected capillaries
  2. ADNC +/CAA +/H donors were three ADNC +/CAA + donors with highly abundant Aβ in capillaries, and ADNC +/CAA +/L donors were three ADNC +/CAA + donors with less abundant Aβ in capillaries
  3. ADNC Alzheimer’s disease neuropathologic change; CAA cerebral amyloid angiopathy
  4. *BH-adjusted p < 0.05, significantly different between two groups
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Fluids and Barriers of the CNS

ISSN: 2045-8118