Fig. 2

CAA-specific changes in protein expression levels of fibrosis-associated molecules in the collected capillaries. For fibrosis-associated molecules listed in Table 2, the graph showing their intergroup comparisons is preferentially presented in this figure. For fibrosis-associated molecules not listed in Table 2 but listed in Table 3 or Additional file 2: Table S2, the correlation graphs with Aβ are shown in this figure if the protein showed a significant correlation both with Aβ (Table 3) and COL6A2 (Additional file 2: Table S2). a ECM-related proteins, b Cell-ECM adhesion-related proteins, c TGF-β signal-related proteins. The data for protein expression levels for individual donors (normalized by average of protein expression levels in ADNC −/CAA − capillaries as described in the "Materials and methods" section) were taken from Additional file 2: Table S1. Black plot, ADNC +/CAA + (CAA); Gray plot, ADNC +/CAA − (AD); White plot, ADNC −/CAA − (Control). For the ADNC +/CAA + group, the three donors with highly abundant Aβ in capillaries (donors 1, 2 and 3) were classified as “ADNC +/CAA +/H”, and the other three donors (donors 4, 5 and 6) were classified as “ADNC +/CAA +/L”. The p-values were taken from Tables 2, 3 or Additional file 2: Table S2. For the correlation graphs, the p-values of “CAA&Control” and “AD&Control” represent the ones in Spearman’s rank correlation using 11 donors (ADNC +/CAA + and ADNC −/CAA −) and 10 donors (ADNC +/CAA − and ADNC −/CAA −), respectively