Fig. 7

Effect of AZE on brain water content and CSF secretion rate. A The brain water content expressed as ml g⁻¹ dry weight (n = 5 in each group, P = 0.5, unpaired t-test) after 1 × daily administration of 100 mg kg⁻¹ p.o. AZE (or control solution) for seven days, measured 24 h after the last dose. Figure B shows the average dextran dye dilution for control and AZE groups as a function of time. The dashed box indicates the period from which the CSF secretion rate was calculated, and the average value for this 20 min period is presented in C (n = 4 in each group, P = 0.4, unpaired t-test). CTRL – control, AZE – acetazolamide. Data are shown as mean ± SD. ns, not significant.