Fig. 2
Effect of i.v. administration of AZE in anesthetized, ventilated and nephrectomized rats. ICP (A), MAP (C) and etCO2 (E) are presented in the same manner as Fig. 1, as well as change at the 2 h after the i.v. injection (100 mg kg−1) for ICP (B, n = 4, PCTRL−CTRL(N) = 0.9, PCTRL(N)−AZE(N) < 0.05, PAZE−AZE(N) = 0.9, 1way ANOVA with Tukey’s post hoc analysis) and MAP (D, n = 4, PCTRL−CTRL(N) < 0.05, PCTRL(N)−AZE(N) = 0.9, PAZE−AZE(N) < 0.05, 1way ANOVA with Tukey’s post hoc analysis). Results from the blood gas analysis are presented for pCO2 (F, n = 4, asterisks show significance for CTRL(N)-AZE(N) comparison – at 0 h, P < 0.001 at 1 and 2 h, 2way ANOVA with Tukey’s post-hoc analysis) and blood HCO3−, (G, n = 4, P < 0.001 for time variable, P = 0.4 for treatment variable, shown above bars, 2way ANOVA). Dark grey and light grey results are obtained from Fig. 1. Arrow indicates time of i.v. injection. ICP – intracranial pressure, MAP – mean arterial pressure, etCO2 – end tidal carbon dioxide, pCO2 – partial carbon dioxide pressure, CTRL – control, AZE – acetazolamide. (N) = nephrectomized rats. Data are shown as mean ± SD. *; P < 0.05, ***; P < 0.001, ns; not significant.