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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease

Fig. 3

HD180 iBMECs exhibit unique gene expression profiles. A Principal component analysis of bulk RNA sequencing. Data collected across n = 2 independent differentiations for each cell line, where iPSC and iBMEC RNA is paired. B Venn diagrams showing overlap of up and downregulated CAG expansion-dependent genes in iBMECs versus iPSCs. C Volcano plots comparing gene expression of iPSC and iBMECs from HD180 (blue) and HD-corrected (red) sources. Selected up and downregulated genes are labeled. D Hallmark gene sets from the Molecular Signatures Database (MSigDB) that are significantly enriched (blue) or depleted (red) in HD180 compared to HD-corrected iBMECs. Significance truncated for gene sets with –log10(adj. P) > 5. E Heatmaps of endothelial, epithelial, or GO term transcript changes between HD180 iBMECs and HD-corrected iBMECs

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