Fig. 4
From: The impact of genetic manipulation of laminin and integrins at the blood–brain barrier
The “green light-red light” model explaining ECM regulation of endothelial cell behavior at the BBB. According to this model, fibronectin-α5β1 integrin and laminin-α6β1 integrin interactions play opposing roles in directing endothelial behavior within CNS blood vessels. Fibronectin-α5 integrin mediated signaling (green arrow) drives vascular remodeling behaviors including endothelial proliferation and migration, while in contrast, laminin-α6β1 integrin mediated signaling (red arrow) promotes endothelial differentiation, resulting in BBB maturation and stabilization