Fig. 3

Principal significant enriched (a) biological functions and (b) canonical pathways determined by Ingenuity Pathway Analysis. Left graphs give comparisons between proteomic profiling of hCMEC/D3 cells culture under 5 dyn.cm⁻² shear stress compared to the static culture, and right graphs show comparisons between proteomic profiling of hCMEC/D3 cells exposed at 10 dyn.cm⁻² shear stress compared to the static condition. Activation z-score depicts the predicted degree of activation (positive z-score in orange) or inhibition (negative z-score in blue). An enrichment is considered significant when − log₁₀(p-value) > 1.3 or |activation z-score|> 2. NaN no activity pattern available, despite significant association of the proteins within the pathway