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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study

Fig. 4

Ptpn20−/− mice develop communicating hydrocephalus. A Sagittal brain section showing acquisition sites of coronal brain slices. Representative micrograph of coronal and HE-stained brain sections showing distances measured for ventricle width (left, a; right, b) and brain width (c) in WT and Ptpn20−/− mice. Ventricle-to-brain ratio (VBR) is calculated as the ratio of the sum of ventricular widths to brain width ((a + b)/c). Ptpn20−/− mouse brain shows dilation of lateral ventricles. Histograms showing the VBR of WT and Ptpn20−/− mice (mean ± standard deviation, Mann-Whitney U test, **P < 0.01; WT, n = 17; Ptpn20−/− mice, n = 29). B Evans Blue injected into the lateral ventricles of Ptpn20−/− mice at 8 weeks old shows slight enlargement of lateral ventricles with dye also seen in the fourth ventricle (n = 5; LV = lateral ventricle; 3V = third ventricle; Aq = aqueduct; 4V = fourth ventricle). Scale bar = 2 mm

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