White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery

Table 5 Linear regression with CSF biomarkers as dependent variables and radiological volumes as independent variables

Biomarker	Volume	B	P-value	n
T-tau	PVH	0.008	0.772	240
	DWMH	0.009	0.717	240
	Lateral ventricles	− 0.474	0.00701**	240
P-tau	PVH	− 0.011	0.58	236
	DWMH	− 0.019	0.273	236
	Lateral ventricles	− 0.135	0.287	236
Aβ1-42	PVH	− 0.032	0.091	237
	DWMH	− 0.017	0.264	237
	Lateral ventricles	− 0.185	0.11	237
NfL	PVH	0.082	0.0852	75
	DWMH	0.048	0.173	75
	Lateral ventricles	− 0.103	0.74	75

Data are adjusted for age, gender, Evans’ index, and DESH
CSF cerebrospinal fluid, DESH disproportionately enlarged subarachnoid space hydrocephalus, B unstandardized regression coefficient, T-tau total tau, PVH periventricular hyperintensities, DWMH deep white matter hyperintensities, P-tau phosphorylated tau, Aβ1-42 amyloid beta1-42, NfL neurofilament light chain protein. Bold values are significant, * < 0.05, ** < 0.01

ISSN: 2045-8118