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Table 5 Linear regression with CSF biomarkers as dependent variables and radiological volumes as independent variables

From: White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery

Biomarker Volume B P-value n
T-tau PVH 0.008 0.772 240
DWMH 0.009 0.717 240
Lateral ventricles − 0.474 0.00701** 240
P-tau PVH − 0.011 0.58 236
DWMH − 0.019 0.273 236
Lateral ventricles − 0.135 0.287 236
Aβ1-42 PVH − 0.032 0.091 237
DWMH − 0.017 0.264 237
Lateral ventricles − 0.185 0.11 237
NfL PVH 0.082 0.0852 75
DWMH 0.048 0.173 75
Lateral ventricles − 0.103 0.74 75
  1. Data are adjusted for age, gender, Evans’ index, and DESH
  2. CSF cerebrospinal fluid, DESH disproportionately enlarged subarachnoid space hydrocephalus, B unstandardized regression coefficient, T-tau total tau, PVH periventricular hyperintensities, DWMH deep white matter hyperintensities, P-tau phosphorylated tau, Aβ1-42 amyloid beta1-42, NfL neurofilament light chain protein. Bold values are significant, * < 0.05, ** < 0.01