White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery

Table 4 Linear regression with baseline symptom scores as dependent variables and radiological volumes as independent variables

Baseline score	Volume	B	P-value	n
Total iNPH scale	PVH	− 0.688	0.242	253
	DWMH	0.075	0.878	253
	Lateral ventricles	3.481	0.333	253
Balance domain	PVH	0.367	0.586	244
	DWMH	1.046	0.0575	244
	Lateral ventricles	3.185	0.44	244
Continence domain	PVH	− 0.303	0.717	246
	DWMH	0.236	0.732	246
	Lateral ventricles	3.862	0.452	246
Gait domain	PVH	− 1.234	0.0979	253
	DWMH	− 0.458	0.458	253
	Lateral ventricles	1.491	0.745	253
Cognitive domain	PVH	− 1.692	0.102	98
	DWMH	− 0.004	0.996	98
	Lateral ventricles	− 8.171	0.231	98
MMSE	PVH	− 0.093	0.489	249
	DWMH	0.170	0.127	249
	Lateral ventricles	− 1.221	0.142	249

Data are adjusted for age, gender, Evans’ index, and DESH
DESH disproportionately enlarged subarachnoid space hydrocephalus, B unstandardized regression coefficient, iNPH idiopathic normal pressure hydrocephalus, PVH periventricular hyperintensities, DWMH deep white matter hyperintensities, MMSE mini-mental state examination

ISSN: 2045-8118