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Table 1 Demographic data, preoperative symptoms, and protein concentrations

From: White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery

Characteristic

Value

n

Age, years, mean (range)

75 (50–89)

253

Male, n (%)

141 (56%)

253

Comorbidity, n (%):

  

 Diabetes

63 (25%)

253

 Hyperlipidemia

96 (38%)

253

 Hypertension

162 (64%)

253

 Previous AMI

37 (15%)

253

 Previous stroke

32 (13%)

253

Aspirin use, n (%)

102 (40%)

253

Oral anticoagulant drug use*, n (%)

18 (7%)

253

Total iNPH scale score, mean (SD)

49.8 (19.0)

253

Separate domain scores, mean (SD)

  

 Balance domain

64.3 (20.9)

244

 Continence domain

59.5 (26.1)

246

 Gait domain

38.9 (24.1)

253

 Cognitive domain

48.9 (21.2)

98

MMSE score, median (IQR)

25.0 (22.0–28.0)

249

Time between preoperative evaluation and surgery, months, median (IQR)

6 (4–8)

253

Protein concentrations, ng/L, median (IQR)

  

 T-tau

211 (150–326)

240

 P-tau

30 (23–39)

236

 Aβ1-42

540 (378–708)

237

 NfL

1200 (790–1730)

75

  1. AMI acute myocardial infarction, iNPH idiopathic normal pressure hydrocephalus, SD standard deviation, MMSE mini-mental state examination, IQR interquartile range, ng nanogram, T-tau total tau, P-tau phosphorylated tau, Aβ1-42 amyloid beta1-42, NfL neurofilament light chain protein
  2. *Warfarin or new oral anticoagulants