Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Andreassen, Søren N.; Toft-Bertelsen, Trine L.; Wardman, Jonathan H.; Villadsen, René; MacAulay, Nanna

doi:10.1186/s12987-022-00335-x

Fluids and Barriers of the CNS

Table 6 Highly transcribed kinases and phosphatases in choroid plexus

From: Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Gene	Alias	TPM	Description
*Kinases*
MAPK4	MAPK4	324	Mitogen-activated protein kinase 4
STK39	SPAK	320	STE20/SPS1-related proline-alanine-rich protein kinase
PINK1	PINK1	196	PTEN induced kinase 1
SGK1	SGK1	134	Serum/glucocorticoid-regulated kinase 1
CSNK1A1	CK1α1	131	Casein kinase 1, α1
MAP2K2	MAPKK2	123	Mitogen-activated protein kinase kinase 2
AKT1	AKT1	121	AKT serine/threonine kinase 1
CSNK2A1	CK2α1	121	Casein kinase 2, α1
CSNK1G2	CK1 γ 2	109	Casein kinase 1, γ2
TGFBR2	TGFBR2	102	Transforming growth factor β receptor 2
MAPK1	MAPK1	92	Mitogen-activated protein kinase 1
DMPK	DM1PK	90	DM1 protein kinase
BCKDK	BCKDK	87	Branched chain ketoacid dehydrogenase kinase
MAPK3	MAPK3	86	Mitogen-activated protein kinase 3
MAPKAPK2	MAPKAP2	75	MAP kinase-activated protein kinase 2
HIPK1	HIPK1	75	Homeodomain-interacting protein kinase 1
PDK3	PDK3	74	Pyruvate dehydrogenase kinase 3
GSK3A	GSK3A	68	Glycogen synthase kinase 3α
SGK3	SGK3	66	Serum/glucocorticoid-regulated kinase 3
MAP2K1	MAPKK1	65	Mitogen-activated protein kinase kinase 1
*Phosphatases*
PPP2CB	PP2B	268	Protein phosphatase 2 Cβ
PTP4A2	PTP4A2	179	Protein tyrosine phosphatase 4A2
PPP1CA	PP1A	136	Protein phosphatase 1 Cα
PPP5C	PP5	118	Protein phosphatase 5 C
PPP1CC	PP1C	105	Protein phosphatase 1 Cγ
CTDSP1	CTDSP1	102	CTD small phosphatase 1
PTPRA	PTPRA	98	Protein tyrosine phosphatase receptor α
PPP1CB	PP1B	86	Protein phosphatase 1 Cβ
PPP2CA	PP2A	85	protein phosphatase 2 Cα
CTDNEP1	CTDNEP1	63	CTD nuclear envelope phosphatase 1
PTPN11	PTPN11	57	Protein tyrosine phosphatase non-receptor 11
MTMR2	MTMR2	55	Myotubularin related protein 2
PPM1F	PPM1F	54	Protein phosphatase, Mg²⁺/Mn²⁺ dependent, 1F
DUSP14	DUSP14	51	Dual specificity protein phosphatase 14
PPM1G	PPM1G	48	Protein phosphatase, Mg²⁺/Mn²⁺ dependent, 1G
PGP	PGP	47	Phosphoglycolate phosphatase
MTMR6	MTMR6	44	Myotubularin related protein 6
PTP4A1	PTP4A1	43	Protein tyrosine phosphatase 4A1
PPP6C	PP6	41	Protein phosphatase 6 C
PPP4C	PP4	40	Protein phosphatase 4 C

RNAseq analysis revealing the 20 highest expressed genes encoding protein kinases (top) and phosphatases (bottom) in choroid plexus. TPM: transcripts per million

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ISSN: 2045-8118

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