Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Andreassen, Søren N.; Toft-Bertelsen, Trine L.; Wardman, Jonathan H.; Villadsen, René; MacAulay, Nanna

doi:10.1186/s12987-022-00335-x

Fluids and Barriers of the CNS

Table 5 Highly transcribed plasma membrane receptors in choroid plexus

From: Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Gene	Alias	TPM	Description
*G protein-coupled receptors*
HTR2C	5-HT2C	677	Serotonin receptor 2C
EDNRB	ETB	150	Endothelin receptor type B
ACKR3	ACKR3	78	Atypical chemokine receptor 3
FZD2	FZ-2	76	Frizzled-2
SMO	FZ-11	62	Frizzled-11
GPR146	GPR146	51	G protein-coupled receptor 146
ADGRG1	GPR56	49	Adhesion G protein-coupled receptor G1
TPRA1	GPR175	42	G protein-coupled receptor 175
FZD7	FZ-7	36	Frizzled-7
GABBR1	GABABR1	32	GABA(B) receptor 1
CRHR2	CRHR2	28	Corticotrophin releasing hormone receptor 2
GPRC5C	GPRC5C	27	G protein-coupled receptor C5C
GPR107	GPR107	23	G Protein-Coupled Receptor 107
ADGRA3	ADGRA3	21	Adhesion G protein-coupled receptor A3
GPR137	GPR137	20	G protein-coupled receptor 137
FZD6	FZ-6	18	Frizzled-6
ADGRL1	ADGRL1	16	Adhesion G protein-coupled receptor L1
LGR4	GPR48	13	G protein-coupled receptor 48
ADGRF5	ADGRF5	12	Adhesion G protein-coupled receptor F5
GPR162	GPR162	12	G protein-coupled receptor 162
*Receptor tyrosine kinases*
FGFR2	FGFR-2	181	Fibroblast growth factor receptor 2
FGFR1	FGFR-1	110	Fibroblast growth factor receptor 1
PDGFRA	PDGFRα	83	Platelet derived growth factor receptor α
NTRK2	NTRK2	75	Neurotrophic receptor tyrosine kinase 2
DDR1	DDR1	54	Discoidin domain receptor tyrosine kinase 1
TYRO3	TYRO3	48	TYRO3 protein tyrosine kinase
RYK	RYK	38	Receptor like tyrosine kinase
KDR	VEGFR2	25	Vascular endothelial growth factor receptor 2
INSR	INSR	24	Insulin receptor
PTK7	PTK7	22	Protein tyrosine kinase 7
PDGFRB	PDGFRβ	20	Platelet derived growth factor receptor β
LMTK2	LMTK2	17	Lemur tyrosine kinase 2
CSF1R	CSF1R	17	Colony-stimulating factor 1 receptor
TIE1	TIE1	16	Tyrosine kinase with immunoglobin- and EGF like domains 1
EPHB4	EPHB4	16	Ephrin receptor B4
FLT1	VEGFR1	15	Vascular endothelial growth factor receptor 1
AXL	AXL	12	AXL receptor tyrosine kinase
FGFR3	FGFR-3	12	Fibroblast growth factor receptor 3
IGF1R	IGF1R	10	Insulin-like growth factor 1 receptor
TEK	TIE2	9	Tyrosine kinase with immunoglobin- and EGF like domains 2

RNAseq analysis revealing the 20 highest expressed genes encoding plasma membrane GPCRs (top) and receptor tyrosin kinases (bottom) in choroid plexus. TPM; transcripts per million

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ISSN: 2045-8118

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